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目的探讨通心络胶囊治疗冠心病心肌缺血的临床效果,对心电图及心肌酶谱的影响。方法选取我院2014年1月~2015年10月收治的80例心肌缺血患者作为研究对象,将其根据随机数字表法分为观察组(n=40)和对照组(n=40)。对照组采用阿司匹林、曲美他嗪常规药物治疗,观察组在此基础上联合通心络胶囊治疗,观察两组患者治疗后临床症状、心电图ST段改变及血清心肌酶的变化。结果观察组的临床症状缓解总有效率为92.5%,显著高于对照组的77.5%(p<0.05);观察组治疗后的24h心电图ST段改变及AST、CK、CK-MB、LDH水平显著低于治疗前及对照组(p<0.05)。结论通心络胶囊可缓解冠心病心肌缺血临床症状,明显改善心肌缺血患者心电图,调节机体内各种酶活性,具有保护缺血心肌损伤的作用,安全有效,值得临床推广使用。
Objective To investigate the clinical effect of Tongxinluo capsule on myocardial ischemia in patients with coronary heart disease and its influence on electrocardiogram and myocardial enzymes. Methods Eighty patients with myocardial ischemia admitted from January 2014 to October 2015 in our hospital were selected and divided into observation group (n = 40) and control group (n = 40) according to random number table. The control group was treated with aspirin and trimetazidine, and the observation group was treated with Tongxinluo capsule. The clinical symptoms, changes of electrocardiogram ST segment and changes of serum myocardial enzymes were observed in the two groups. Results The total effective rate of clinical symptoms relieved in the observation group was 92.5%, which was significantly higher than that in the control group (77.5%, p <0.05). ST-segment changes and AST, CK, CK-MB and LDH levels in the observation group were significant Lower than before treatment and control group (p <0.05). Conclusion Tongxinluo capsule can relieve the clinical symptoms of myocardial ischemia in patients with coronary heart disease. It can obviously improve the electrocardiogram of patients with myocardial ischemia and regulate the activity of various enzymes in the body. It has the function of protecting ischemic myocardial injury and is safe and effective. It is worth to be used clinically.