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为探讨国产规范化甲肝减毒活疫苗（ＬＡ－１株）免疫两针的抗体水平和适宜程序，将６～１０岁的抗ＨＡＶ－ＩｇＧ阴性儿童分为Ａ、Ｂ两组。分别按０，６程序和０，１２程序进行接种（疫苗滴度为１０６．７５ＴＣＩＤ５０）。于第２针免后１个月采血，用Ａｂｂｏｔｔ公司的ＩＭｘｍＥＩＡ试剂及相应的自动检测仪检测血清抗ＨＡＶ－ＩｇＧ和滴度。结果，两组的抗体阳转率均为１００％，０，１２程序组的ＧＭＴ（３１４５．４ｍＩＵ／ｍｌ）远高于０，６程序组（１２０４．６ｍＩＵ／ｍｌ），接近国外甲肝灭活疫苗完成两针后的抗体水平。两针法的抗体阳转率高于１针法，ＧＭＴ是１针法的１０～２６倍，以０，１２程序为佳。
In order to explore the antibody level and the suitable procedure of immunization of live attenuated hepatitis A virus (LA-1 strain) in China, anti-HAV-IgG negative children aged 6-10 years old were divided into A and B groups. Vaccination was carried out according to 0,6 program and 0,12 program respectively (vaccine titer was 106.75 TCID50). Blood samples were taken 1 month after the second injection, and serum anti-HAV-IgG and titer were measured using Abx’s IMxmEIA reagent and the corresponding automatic detector. As a result, the positive rate of antibody positive in both groups was 100%. The GMT (3145.4mIU / ml) in the 0,12 program group was much higher than that in the 0,6 program group (1204.6mIU / ml), close to the foreign hepatitis A inactivated vaccine Complete antibody levels after two needles. Antibody positive rate of the two-stitch method is higher than that of the first stitch method, and GMT is 10 to 26 times of that of the first stitch method.