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目的分析广东省潮州市正常体检妇女的人乳头瘤病毒(HPV)和沙眼衣原体(CT)感染之间的关联性。方法采用HPV基因芯片筛查1705名体检妇女的HPV,并对其进行基因分型。实时荧光定量PCR检测154例HPV阳性标本的衣原体感染情况,使用100份HPV阴性的样本作为对照组。结果潮州市妇女HPV感染率为9.03%。共检出14种高危型HPV,占阳性标本比率的72.3%,比率前两位的基因型为52、58型。高危型HPV感染群体的CT感染率为29.4%,低危型HPV群体的CT感染率为4.7%,HPV阴性人群的CT感染率为5%,高危型与低危型和HPV阴性人群的CT感染率均有显著性差异(χ2=10.60;P<0.05)(χ2=21.43;P<0.05),低危型人群及HPV阴性人群的CT感染率无显著性差异(χ2=0.003;P>0.05)。结论本次研究提供了潮州地区CT及HPV感染的流行病学数据。同时证明了在“正常”体检妇女中,高危型HPV病毒感染与衣原体的感染具有较强的相关性。
Objective To analyze the association between human papillomavirus (HPV) and Chlamydia trachomatis (CT) in normal physical examination women in Chaozhou, Guangdong Province. Methods The HPV gene chips were used to screen HPV of 1705 women and to genotype them. Real-time PCR was used to detect chlamydial infection in 154 HPV-positive specimens. 100 HPV-negative specimens were used as control group. Results The prevalence of HPV infection in Chaozhou women was 9.03%. A total of 14 high-risk HPVs were detected, accounting for 72.3% of the positive samples. The top two ratios of genotypes were 52 and 58. The rate of CT infection in high-risk HPV infection population was 29.4%, that in low-risk HPV population was 4.7%, that of HPV negative population was 5%, and CT infection in high-risk and low-risk and HPV-negative patients (Χ2 = 10.60; P <0.05) (χ2 = 21.43; P <0.05). There was no significant difference in CT infection rates between low-risk group and HPV-negative group (χ2 = 0.003; . Conclusion This study provided epidemiological data on CT and HPV infection in Chaozhou area. At the same time, it has been proved that there is a strong correlation between high-risk HPV infection and Chlamydia infection in “normal” women.