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目的分析邯郸地区新生儿血培养病原菌分布及其耐药情况,为指导临床诊断及合理应用抗生素提供客观依据。方法对我院2007年1月～2009年1月新生儿血培养阳性标本共122份进行细菌鉴定并药敏结果分析。结果122例阳性标本中凝固酶阴性葡萄球菌占51.6%,金黄色葡萄球菌11.5%,二者对多种抗生素耐药,其中苯唑西林的耐药率分别为68.3%、57.1%,对万古霉素和替考拉宁100%敏感;革兰阴性菌中肺炎克雷伯氏菌占首位,其次为大肠埃希氏菌,抗菌活性较好的药物是亚胺培南、美罗培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦。结论本地区新生儿血培养病原菌以凝固酶阴性葡萄球菌最多见,具有多重耐药性,临床医师应根据细菌鉴定及药敏试验选择敏感药物治疗。
Objective To analyze the distribution and drug resistance of neonatal blood cultures in Handan and provide an objective basis for clinical diagnosis and rational use of antibiotics. Methods A total of 122 positive samples of neonatal blood cultures from January 2007 to January 2009 in our hospital were identified and their susceptibility results were analyzed. Results In 122 positive samples, coagulase-negative staphylococci accounted for 51.6% and Staphylococcus aureus was 11.5%. Both of them were resistant to many antibiotics. The resistance rates of oxacillin were 68.3% and 57.1% Klebsiella pneumoniae and Klebsiella pneumoniae were 100% sensitive. Klebsiella pneumoniae was the most common in Gram-negative bacteria, followed by Escherichia coli. The drugs with better antibacterial activity were imipenem, meropenem and piperacillin / Tazobactam, cefoperazone / sulbactam. Conclusion Neisseria gonorrhoeae is the most common coagulase-negative Staphylococcus aureus in neonates in this area. It is multi-drug resistant. Clinicians should select sensitive drugs based on bacterial identification and susceptibility testing.