血管内皮是覆盖血管内腔的一层细胞,一直被认为它只是血液与血管及其周围组织之间的一种屏障。作为运输机构,它的首要机能便是搬运血中物质到周围组织去。但是,后来明确,内皮细胞功能不止如此,还有其他。一、内皮细胞的抗凝血功能血管内皮细胞的抗凝血性,在于使正常血液在血管中不凝。而流到血管外的血液,一旦发生凝固凝血机制即不停止。然而,在体内即使血管损伤引起血凝,亦仅限于损伤部位,正常血管内流动着的血液,尽管环境变化颇大,并不发生凝血。内皮细胞抗凝是内皮细胞表面存在凝血调节因子。该因子在内皮细胞表面与凝血酶结合后,可改变凝血酶固有凝血功能为非凝血性质。在凝血酶使血小板活化能力降低的同时,已不具备凝血功能的凝血酶激活蛋白 C,可使凝血因子Ⅴa、(?)a 失活,而表现抗 The vascular endothelium is a layer of cells that covers the lumen of blood vessels and has long been considered as a barrier between blood and blood vessels and their surrounding tissues. As a transportation agency, its primary function is to carry blood substances to the surrounding tissues. However, it became clear later that endothelial function did not stop there, there were others. First, the anticoagulant function of endothelial cells Vascular endothelial cell anticoagulant, is that the normal blood vessels in the non-condensing. The blood flow to the blood vessels, coagulation and coagulation mechanisms in the event that does not stop. However, even if blood vessel damage causes blood clotting in the body, it is limited to the site of injury and the blood flowing in the normal blood vessels does not coagulate in spite of the large environmental changes. Endothelial cell anticoagulation is a coagulation regulator on the surface of endothelial cells. The factor in the endothelial cell surface with thrombin, thrombin can change the inherent coagulation non-coagulation properties. In the thrombin to platelet activation ability while reducing, already do not have the thrombin activating protein C coagulation, coagulation factor Va, (?) A inactivation, and performance of anti