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在建立阻塞性豚鼠膜迷路积水模型的基础上,用氢廓清法分组测定膜迷路积水耳蜗外侧壁的血流量。结果:本组动物积水发生率为77.78%,耳蜗组织病理学改变主要在顶回。血流量测定在术后30天以后有显著减少。积水在前,血流量减少在后,提示膜迷路积水可能因积水过重,时间过长而引起耳蜗血流量减少,两者可互为因果。本文将氢廓清法测定组织血流量与微球法、激光多普勒法进行了比较,认为前者具有定位准确、可持续测定和动态观察、测定血流以绝对量表示等优点。并对积水时蜗顶损害现象进行了分析讨论。
On the basis of establishing obstructive guinea pig membranous labyrinthine hydrocephalus model, the blood flow of the hydrocephalic outer lateral wall of membranous labyrinthine membrane was determined by the hydrogen clearance method. Results: The incidence of hydrocephalus in this group was 77.78%, and the histopathological changes in the cochlea were mainly in the top. Blood flow measurement after 30 days after a significant reduction. Hydrocephalus in the former, after the reduction in blood flow, suggesting that the membrane lost water may be due to hydrocephalus, over time caused by reduced cochlear blood flow, the two can be mutually causal. In this paper, the hydrogen clearance determination of tissue blood flow and the microsphere method, laser Doppler method were compared, that the former has the positioning accuracy, continuous measurement and dynamic observation, determination of blood flow in absolute terms, and other advantages. The phenomenon of water damage on the top of the cochlear is analyzed and discussed.