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为有效地从繁多的中药复方化合物中发现和辨识出其作用成分,明确中药作用功效提供参考和依据,通过对中国知网和国外相关杂志的文献进行检索和总结,从26篇近期报道的文献中提炼出有效成分辨识相关思路,对以药理活性为向导的有效成分辨识和基于体内过程的有效成分辨识这2个主要研究方法分别进行归纳,并着重对基于体内过程有效成分辨识的常用技术如外翻肠囊法、Caco-2细胞模型、血清药物化学法进行了总结。传统的以药理活性向导的中药有效成分辨识和近期发展的基于体内过程进行中药活性物质筛选均有各自的优势和不完善之处,综合应用可以达到良好的互补。同时,多成分综合作用是中药发挥效果的基本模式,因此,进行有效成分辨识时,在多成分综合效应中辨识出主要的有效成分,是符合中药特点的有效成分辨识方法。
In order to effectively find out and identify its active ingredients from a large number of traditional Chinese medicine compound compounds, and to provide a reference and basis for clarifying the effect of traditional Chinese medicine, we search and summarize the literature of China Knitting Network and related foreign journals from 26 recently reported articles In order to extract the relevant ideas of active ingredient identification, summarize the two main research methods of effective ingredient identification based on pharmacological activity guidance and active ingredient identification based on in vivo process, and focus on the common technologies based on the identification of active ingredients in vivo Valgus gut method, Caco-2 cell model, serum drug chemistry were summarized. Traditional active pharmacological guidance of traditional Chinese medicine active ingredient identification and the recent development of the process of screening traditional Chinese medicine active substances have their own advantages and imperfections, comprehensive application can achieve good complementarity. At the same time, the multi-component comprehensive effect is the basic mode of traditional Chinese medicine to exert its effect. Therefore, identifying the main active ingredients in the multi-component comprehensive effect is an effective component identification method that accords with the characteristics of traditional Chinese medicine.