,De Novo Plant Genome Assembly Based on Chromatin Interactions: A Case Study of Arabidopsis thaliana

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Dear Editor,Genome assembly is typically a two-stage process:paired sequencing reads are joined into contigs,and contigs are assembled into scaffolds.Over the past 10 years,next-generation sequencing (NGS) technologies have become inexpensive,routine,and widespread.As a result,most plant genomes that are sequenced by NGS produce "drafts" that are always contig or scaffold maps remaining in a more or less advanced stage of completion (Claros et al.,2012).Slow advances in the technology for the de novo assembly of scaffolds into chromosome-scale scaffolds have become the main restriction to the completion of and high-quality genome sequence acquisition.
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