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目的总结52例连续肾脏替代治疗(CRRT)重症有机磷中毒患者的疗效。方法选取2014年6月~2016年6月期间本院收治的52例重症有机磷中毒患者作为研究对象,所有患者均接受CRRT。观察患者治疗的预后情况,记录患者的ICU住院时间及总住院时间,记录患者的昏迷时间、胆碱酯酶(Ch E)恢复时间及阿托品用量。结果 52例患者中3例(5.77%)治疗过程中死亡,2例(3.85%)患者因经济困难放弃治疗,47例(90.38%)患者病情稳定后由ICU转入普通病房,治愈后出院;患者中位ICU住院时间141h(98~241 h),中位总住院时间235.5 h(98~512 h),中位昏迷时间12.5 h(7~24h),中位Ch E恢复时间112 h(72~196 h),中位阿托品用量194.5 mg(79~650 mg)。结论 CRRT在重症有机磷中毒治疗中具有一定的疗效,但也给医护工作者带来挑战,护理人员在治疗过程中需要严密关注患者的病情变化。
Objective To summarize the curative effect of 52 cases of patients with severe organophosphate poisoning treated with continuous renal replacement therapy (CRRT). Methods Fifty-two patients with severe organophosphate poisoning admitted to our hospital from June 2014 to June 2016 were selected as the study subjects. All patients received CRRT. Observe the prognosis of patients treated, record the patient’s ICU length of stay and hospital stay, and record the patient’s coma, cholinesterase (ChE) recovery time and atropine dosage. Results Three of the 52 patients (5.77%) died during the treatment. Two patients (3.85%) gave up their treatment because of financial difficulties. Forty-seven patients (90.38%) were transferred to the general ward after their condition was stable. The median hospital stay was 141 h (98-241 h), median total hospital stay was 235.5 h (98-512 h), median coma was 12.5 h (7-24 h), median Ch E recovery time was 112 h (72 ~ 196 h), median dose of atropine 194.5 mg (79 ~ 650 mg). Conclusion CRRT has a certain effect in the treatment of severe organophosphorus poisoning, but it also poses a challenge for health care workers. Caregivers need to pay close attention to the patient’s condition during the treatment.