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[背景]观察来曲唑在促排卵治疗中的临床效果.[病例报告]选择120例接受促排卵治疗者,随机分为2个组,分别为来曲唑A组及氯米芬组,每组各为60例,分别口服给予来曲唑、氯米芬3个周期;来曲唑B组为氯米芬组3个周期不排卵或发生卵泡黄素华未破裂(LUF)后停药3个月,改口服来曲唑3个周期的患者.来曲唑A组共为148个周期,氯米芬组为160个周期,来曲唑B组为86个周期.观察来曲唑A组及氯米芬组的子宫内膜厚度、成熟卵泡数、排卵率、发生LUF数、卵巢过度刺激(OHSS)数及妊娠率,并进行比较;观察氯米芬无效而改用来曲唑后的临床效果.来曲唑A组人绒毛膜促性腺激素(hCG)日成熟卵泡数为1.12±0.20,明显少于氯米芬组成熟卵泡数1.45±0.77(P<0.05);HCG日子宫内膜厚度达不到8mm者占7.4%,明显少于氯米芬组的35.6%(P<0.05);来曲唑组发生LUF,OHSS均显著少于氯米芬组(P<0.05);排卵率81.2%明显高于氯米芬组的60.3%(P<0.05).来曲唑B组由氯米芬改服来曲唑后18例排卵,8例妊娠成功.[讨论]来曲唑促排卵临床效果优于氯米芬,并可使部分对氯米芬无效患者成功促排卵,减少LUF,OHSS等并发症,可成为氯米芬的替代药物.
[Background] To observe the clinical effect of letrozole in the treatment of ovulation [Case Report] Select 120 cases of ovulation induction treatment were randomly divided into two groups, respectively Letrozole A group and clomiphene citrate group, each Each group was 60 cases, were given orally letrozole, clomiphene citrate three cycles; letrozole B group clomiphene citrate 3 cycles without ovulation or follicular flavin glomerular rupture (LUF) withdrawal 3 months , To change oral letrozole 3 cycles of patients.Letrazole A group of 148 cycles, clomiphene citrate group of 160 cycles, letrozole B group of 86 cycles.Effects of letrozole A group and chlorine Endometrial thickness, number of mature follicles, ovulation rate, LUF number, ovarian hyperstimulation (OHSS) number and pregnancy rate in the mifeprist group were compared and compared. The clinical effect of clomiphene after switching to letrozole was not observed The number of mature follicles in lechopril A group was 1.12 ± 0.20, significantly less than that in clomiphene group (1.45 ± 0.77, P <0.05), and the endometrial thickness at HCG was The incidence of LUF and OHSS in the letrozole group was significantly less than that in the clomiphene group (P <0.05), and the ovulation rate was 81.2% Significantly higher than chloride (P <0.05) .Lettrozole group B changed from clomiphene to letrozole after ovulation in 18 cases, 8 cases of pregnancy success [Discussion] letrozole ovulation is superior to clomiphene in clinical efficacy, And can make some patients with clomiphene invalid ovulation, reduce LUF, OHSS and other complications, can be an alternative to clomiphene.