口腔粘膜下纤维样变性(OSMF)是一种病因不明、隐袭发生的慢性疾病,整个口腔均可受累。其基本变化是继水泡形成之后粘膜固有层的结缔组织弹力纤维变性,在病程后期口腔粘膜僵硬,患者常有牙关紧闭而导致进食困难。本文报道作者等2年半来治疗的经验。研究对象系印度新德里96名病人。临床作出诊断,便在局麻下做深的楔形活检,予 Oral submucosal fibrosis (OSMF) is a chronic disease in which the etiology is unknown and the insidiousness occurs. The entire oral cavity can be affected. The basic change is the degeneration of the connective tissue elastic fibers in the lamina propria mucosa after the formation of the blisters. In the late stage of the course of the disease, the oral mucosa is stiff, and patients often have the teeth closed and lead to eating difficulties. This article covers the author's experience of 2 and a half years of treatment. The study was conducted in 96 patients in New Delhi, India. Clinical diagnosis, then under local anesthesia to do deep wedge biopsy, to