目的探讨养血清脑颗粒联合尼莫地平治疗慢性脑供血不足(CCCI)对血管内皮功能的影响。方法 78例CCCI患者随机分为观察组与对照组,各39例。两组均给予常规内科药物治疗,观察组在此基础上给予养血清脑颗粒联合尼莫地平治疗。对比两组血管内皮功能情况。结果观察组治疗后一氧化氮(NO)、血管内皮素-1(ET-1)及内皮依赖性血管舒张功能(EDD)优于对照组(P<0.05),两组非内皮依赖性血管舒张功能(NEDD)比较,差异无统计学意义(P>0.05)。结论养血清脑颗粒与尼莫地平联合应用可显著改善CCCI患者的血管内皮功能,值得临床进一步推广使用。 Objective To investigate the effects of Yangxue Qingnao Granules combined with nimodipine on vascular endothelial function in patients with chronic cerebral hypoperfusion (CCCI). Methods A total of 78 patients with CCCI were randomly divided into observation group and control group, 39 cases in each group. Both groups were given conventional medical treatment, the observation group on the basis of nourishing qingnao granules combined with nimodipine treatment. Compare the two groups of vascular endothelial function. Results The levels of NO, ET-1 and endothelium-dependent vasodilatation (EDD) in the observation group were better than those in the control group (P <0.05), and the endothelium-dependent vasodilation (NEDD), the difference was not statistically significant (P> 0.05). Conclusion Yangxue Qingnao Granules combined with nimodipine can significantly improve the endothelial function of CCCI patients, it is worth further clinical use.