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目的探讨股骨促结缔组织增生性纤维瘤(DF)的临床病理特征及诊断与鉴别诊断。方法对2例股骨DF进行病理形态和免疫组化观察,结合临床资料进行分析并复习相关文献。结果组织学特点:肿瘤由梭形瘤细胞和大量胶原构成,胶原纤维密集而粗大,呈波浪状或束状,瘤细胞核形态温和,肿瘤多呈浸润性生长。免疫组化:瘤细胞-βcatenin(2/2)、Vimentin(2/2),Desmin、SMA局灶(+)。结论骨DF具有较强的局部侵袭能力,切除不彻底容易复发,应手术广泛全切。联合检测-βcatenin、SMA、Vim、Desmin等标记物对骨DF诊断和鉴别诊断具有重要意义。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of femoral connective tissue proliferative fibromatosis (DF). Methods Two cases of femur DF were observed by pathology and immunohistochemistry, combined with clinical data analysis and review of relevant literature. Results Histological features: The tumor consisted of spindle-shaped tumor cells and a large amount of collagen. The collagen fibers were dense and coarse, with wavy or bundles. The tumor nuclei were mild and the tumors mostly showed invasive growth. Immunohistochemistry: tumor cells -βcatenin (2/2), Vimentin (2/2), Desmin, SMA focal (+). Conclusion Bone DF has a strong local invasion ability, resection is not completely easy to relapse, surgery should be a full cut. Joint detection of beta-catenin, SMA, Vim, Desmin and other markers on bone DF diagnosis and differential diagnosis is of great significance.