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目的:探讨急性冠脉综合征患者中脂蛋白相关磷脂酶A2(Lp-PLA_2)水平与冠心病严重程度的关系。方法:通过回顾性病例研究,选取急性冠脉综合征并且行冠脉造影患者168例,检测血清Lp-PLA_2水平。根据GRACE评分以及SYNTAX积分不同各分为三组,比较各组间LpPLA_2水平,分析Lp-PLA_2与急性冠脉综合征的冠脉严重程度及危险程度等的相关性。结果:根据GRACE评分不同,三组间Lp-PLA_2差异具有统计学意义(P=0.00),GRACE评分越高,Lp-PLA_2越高;根据SYNTAX积分不同,三组间Lp-PLA_2差异具有统计学意义(P=0.00),SYNTAX积分越高,Lp-PLA_2越高。结论:Lp-PLA_2水平随着GRACE评分、SYNTAX积分增加而升高,预示血清Lp-PLA_2水平与冠脉病变严重程度相关,与急性冠脉综合征危险程度以及预后有着密切的关系。
Objective: To investigate the relationship between the level of lipoprotein-associated phospholipase A2 (Lp-PLA_2) and the severity of coronary heart disease in patients with acute coronary syndrome. Methods: A retrospective case study of 168 patients with acute coronary syndrome who underwent coronary angiography was performed. Serum Lp-PLA 2 levels were measured. According to GRACE score and SYNTAX score, each group was divided into three groups. The levels of LpPLA_2 in each group were compared, and the relationship between Lp-PLA_2 and severity and degree of coronary artery disease in acute coronary syndrome were analyzed. Results: According to GRACE score, the difference of Lp-PLA_2 between the three groups was statistically significant (P = 0.00). The higher the GRACE score, the higher the Lp-PLA_2. According to SYNTAX score, the differences of Lp-PLA_2 between the three groups were statistically significant Significance (P = 0.00), the higher the SYNTAX score, the higher the Lp-PLA_2. CONCLUSION: Lp-PLA_2 level increases with GRACE score and SYNTAX score. It indicates that serum Lp-PLA_2 level correlates with the severity of coronary artery disease and is closely related to the risk of acute coronary syndrome and prognosis.