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目的探讨匹多莫德对老年慢性阻塞性肺疾病(COPD)患者免疫功能的影响。方法收集住院老年COPD患者随机分成2个组,对照组给予抗生素静脉给药,给药组除静脉给予抗生素治疗外,同时口服匹多莫德80mg,每日2次,给药10天。结果CD3+、CD4+分子在老年COPD给药组中前、后组间比较有统计学意义(aP<0.01);在老年COPD给药组中给药后与给老年COPD对照组治疗后组间比较差异显著(bP<0.05);CD8+分子在各组间均无显著差异性。lgG在老年COPD给药组中给药前、后有显著差异(cP<0.05),老年COPD给药组与老年COPD对照组治疗后组间比较除lgG有显著差异外(cP<0.05),lgM、lgA均无差异性。结论匹多莫德可以调节老年COPD患者的免疫功能,尤其可以提高IgG的水平。
Objective To investigate the effect of pidotimod on immune function in elderly patients with chronic obstructive pulmonary disease (COPD). Methods Aged COPD patients were randomly divided into two groups. The control group received intravenous antibiotics. The patients in the control group received pidotimod 80 mg twice daily for 10 days. Results Before and after treatment, the levels of CD3 + and CD4 + in elderly COPD patients were statistically significant (aP <0.01). Compared with the control group, the difference was statistically significant Significant (bP <0.05). There was no significant difference in CD8 + molecule among the groups. lgG in the elderly COPD treatment group before and after treatment were significantly different (cP <0.05), the elderly COPD treatment group and elderly COPD control group after treatment compared with lgG significant difference (cP <0.05), lgM , LgA no difference. Conclusion Pidotimod can regulate the immune function of elderly patients with COPD, in particular, can increase the level of IgG.