The increasing morbidity of intal diseases poses serious threats to human health and quality of life. Exhaled breath analysis is a noninvasive and convenient diagnostic method to improve the cure rate of patients. In this study, a self-powered breath analyzer based on polyaniline/polyvinylidene fluoride (PANI/PVDF) piezo-gas-sensing arrays has been developed for potential detection of several intal diseases. The device works by converting exhaled breath energy into piezoelectric gas-sensing signals without any extal power sources. The five sensing units in the device have different sensitivities to various gas markers with concentrations ranging from 0 to 600 ppm. The working principle can be attributed to the coupling of the in-pipe gas-flow-induced piezoelectric effect of PVDF and gas-sensing properties of PANI elec-trodes. In addition, the device demonstrates its use as an ethanol analyzer to roughly mimic fatty liver diagnosis. This new approach can be applied to fabricating new exhaled breath analyzers and promoting the development of self-powered systems.