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为了探讨胆汁返流(BR)的发生机理,本文研究了BR性胃炎患者胃、十二指肠(D)粘膜胃肠激素(GH)的含量及其意义。结果表明,胃粘膜生长抑素(SS)(P<0.025),血管活性肠肽(VIP)(P<0.001)含量明显减少,胃动素(MT)、血管加压素(AVP)含量亦降低;脑啡呔(ME)(P<0.025)、β—内啡呔(β—EP)(P<0.001)含量显著增加。D粘膜SS(P<0.005)、(β—EP)(P<0.001)、VIP(P<0.001)含量著减少;MT(P<0.05)、AVP(P<0.025)显著增加。胃粘膜病变程度与ME(P<0.05)和VIP(P<0.025)含量呈正相关,与β—EP及MT呈负相关。提示粘膜GH参与胃、幽门和D运动的调节及BR的发生。
In order to explore the pathogenesis of bile reflux (BR), we studied the content and significance of gastrointestinal hormone (GH) in the stomach and duodenum (D) of patients with BR gastritis. The results showed that the content of gastric mucosal somatostatin (SS) (P <0.025) and vasoactive intestinal peptide (VIP) (P <0.001) were significantly decreased, and the content of motilin (MT) and vasopressin ; MEK (P <0.025), β-EP (P <0.001) increased significantly. D, mucosal SS (P <0.005), (β-EP) (P <0.001), and VIP (P <0.001) decreased; MT (P <0.05) and AVP (P <0.025) increased significantly. The degree of gastric mucosal lesions was positively correlated with ME (P <0.05) and VIP (P <0.025), negatively correlated with β-EP and MT. Suggest that mucosal GH involved in the regulation of stomach, pylorus and D movement and the occurrence of BR.