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1.甲素及乙素預先作靜脉注射,能使乙醯胆硷的降压作用加强及作用时間延長,同时阿託品可部分取消甲素及乙素的降压作用,可以認为其有拟似胆硷反应系統(M-系統)的作用。 2.甲素及乙素对腎上腺素之升压作用並無影响。 3.甲素及乙素对交感神經节並無阻断作用,相反,当甲素及乙素产生显著血压下降时,往往引起交感神經节的短暫兴奋現象。 4.甲素及乙素可取消或減弱因压迫頸动脉所引起的升压反射,二者的降压作用並不受切断二侧竇神經所影响,可以推想其对血管运动中樞或交感神經中樞有抑制作用。 5.甲素及乙素对血管的直接及反射性舒張作用,对血管运动中樞或交感中樞之抑制及对胆硷反应系統的拟似作用等,应可視为它們降压作用之主要机制。 6.甲素及乙素之药理性質相似,但乙素之降压作用較甲素为弱且易产生急速耐受現象。
1. A and B pre-intravenous injection, can enhance the role of antihypertensive acetylcholine and the role of prolonged time, while atropine can partially cancel the antihypertensive effect of alpha and beta, it can be considered There is a quasi-choline reaction system (M-system) role. A and B on the role of the epinephrine boost has no effect. A and B on the sympathetic ganglia did not block the role, on the contrary, when a and B produced a significant drop in blood pressure, often cause sympathetic ganglia transient excitement phenomenon. A and B can cancel or reduce due to compression of the carotid artery caused by the pressure reflex, both antihypertensive effect is not affected by the cut off both sides of the sinus nerves, it can be presumed that the vascular motor center or sympathetic nerve center Inhibit effect. A and B on blood vessels directly and reflexive relaxation of the vasomotor center or sympathetic center of the quasi-cholinergic reaction system and the like, should be considered as the main mechanism of their antihypertensive effect. The pharmacological properties of A and B are similar, but the antihypertensive effect of B is weaker than that of A and it is easy to produce rapid tolerance.