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目的 研究恶性淋巴瘤的临床、病理特点。方法 根据WHO(1997)分类标准对 370例恶性淋巴瘤患者进行临床、病理及免疫表型分析。结果 非霍奇金淋巴瘤 (NHL) 35 9例 ,占 97.0 3% ;霍奇金淋巴瘤 (HL) 11例 ,占 2 .97%。NHL中 ,B细胞淋巴瘤 2 4 6例 ,占 6 8.5 2 % ;T细胞淋巴瘤 10 8例 ,占30 0 8% ;组织细胞性淋巴瘤和滤泡树突状细胞肉瘤各 1例 ,NK细胞性淋巴瘤 3例。结外淋巴瘤 (196例 ,占 5 4 .6 % )多于结内淋巴瘤 (16 3例 ,占 4 5 .4 % )。NHL中发病率较高的淋巴瘤类型依次为 :弥漫大B细胞淋巴瘤 (173例 ,占 4 8.2 % ) ,外周非特殊T细胞淋巴瘤 (5 4例 ,占 15 .0 % ) ,黏膜相关淋巴组织细胞淋巴瘤 (31例 ,占 8.6 % ) ,NK/T细胞淋巴瘤 (2 5例 ,占 7.0 % ) ,滤泡性淋巴瘤 (2 1例 ,占 5 .8% ) ,间变性T细胞淋巴瘤 (12例 ,占 3.3% )。结论 应用WHO(1997)分类对恶性淋巴瘤进行分析研究 ,具有重要的临床意义。
Objective To study the clinical and pathological features of malignant lymphoma. Methods The clinical, pathological and immunophenotypic characteristics of 370 patients with malignant lymphoma were analyzed according to WHO (1997) classification. Results Non-Hodgkin’s lymphoma (NHL) 35 9 cases, accounting for 97.0%; Hodgkin’s lymphoma (HL) 11 cases, accounting for 2.97%. NHL, 246 cases of B cell lymphoma, accounting for 8.552%; T cell lymphoma 108 cases, accounting for 30 0%; histiocytic lymphoma and follicular dendritic cell sarcoma in 1 case, NK 3 cases of cell lymphoma. Extranodal lymphoma (196 cases, 54.6%) was more frequent than intra-nodular lymphoma (163 cases, 45.5%). The most common types of lymphoma in NHL were diffuse large B cell lymphoma (173 cases, accounting for 4.82%), peripheral non-specific T cell lymphoma (54 cases, 15.0%), mucosal correlation Lymphohistiocytic lymphoma (31 cases, 8.6%), NK / T cell lymphoma (25 cases, 7.0%), follicular lymphoma (21 cases, 5.8%), anaplastic T Cell lymphoma (12 cases, 3.3%). Conclusion The classification of malignant lymphoma by WHO (1997) has important clinical significance.