论文部分内容阅读
目的探讨辛伐他汀对中老年高血压患者颈动脉粥样硬化的影响。方法中老年高血压合并颈动脉粥样硬化患者95例,随机分为血脂异常高血压合并颈动脉硬化35例(A组),血脂正常高血压合并颈动脉硬化30例(B组),余30例为对照组(C组)。在常规降压、降糖、抗血小板聚集治疗基础上,A组、B组每晚加用辛伐他汀20mg。分别于治疗前及治疗后6个月测定总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C);彩色多普勒超声检测记录颈动脉内膜-中膜厚度(IMT),并计算颈动脉斑块积分,斑块检出率。结果 C组治疗前后TC、TG、LDL-C、HDL-C水平差异无统计学意义(P>0.05),治疗后IMT、斑块积分上升(P<0.05),斑块检出率增加。A组、B组治疗后除HDL-C上升外,其余血脂指标、IMT及颈动脉斑块积分均较治疗前下降(P<0.05、P<0.01),斑块检出率下降。结论辛伐他汀能延缓和逆转血脂异常或血脂正常中老年高血压患者颈动脉粥样硬化进展,具有稳定斑块作用。
Objective To investigate the effect of simvastatin on carotid atherosclerosis in middle-aged and elderly hypertensive patients. Methods A total of 95 elderly patients with hypertension and carotid atherosclerosis were randomly divided into 35 cases with dyslipidemia and carotid atherosclerosis (group A), 30 cases with hyperlipidemia and carotid atherosclerosis (group B), more than 30 Example for the control group (C group). In the conventional antihypertensive, hypoglycemic, anti-platelet aggregation therapy based on the group A, B plus simvastatin 20mg nightly. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured before treatment and 6 months after treatment respectively. Color Doppler Carotid intima-media thickness (IMT) was recorded by ultrasound, and carotid plaque score and plaque detection rate were calculated. Results The levels of TC, TG, LDL-C and HDL-C in group C before treatment were not significantly different (P> 0.05). After treatment, IMT and plaque score increased (P <0.05), and the detection rate of plaque increased. In addition to HDL-C increase in group A and group B, the levels of other lipids, IMT and carotid artery plaque score were lower than those before treatment (P <0.05, P <0.01), and the plaque detection rate decreased. Conclusion Simvastatin can delay and reverse the progression of carotid atherosclerosis in patients with dyslipidemia or normal lipid levels and has stable plaque.