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目的 为探讨艾滋病高效抗逆转录病毒治疗、疗效观察及其对免疫功能的影响.方法 应用HAART疗法对4例有严重免疫功能低下的HIV/AIDS病人进行治疗.结果 所有病人在治疗4周HIV复制被明显抑制,血浆病毒载量平均下降1.99log/ml(0.73～2.46log/ml),CD_8~+、CD_4~+细胞和血浆IL-2浓度在4～12周后持续性显著增高,上升幅度分别为67.2%,103.0%,255.1%,而血浆sIL-2R、IL-6、TNF-α、sTNFR-I、Neopterin浓度在治疗4～12周后持续下降至正常水平或以下.HAART治疗后各因素变化间的相关性分析显示,CD_4~+细胞数与CD_8~+、CD_3~+细胞和血浆IL-2浓度之间,血浆病毒载量与sIL-2R、IL-6、TNF-α、sTNFR-I、Neopterin之间,sTNFR-I和Neopterin与sIL-2R、IL-6、TNF-α之间均存在明显正直线相关性;而CD_4~+细胞数与血浆病毒载量、sIL-2R、sTNFR-I、Neopterin之间.以及IL-2和sIL-2R之间则有明显负直线相关性.结论 抗病毒治疗效果、病毒复制和免疫活化间具有密切关系,HAART治疗能快速有效地抑制HIV-1的复制,纠正机体免疫功能紊乱和重建免疫功能;外周血CD_4~+细胞数、血浆病毒载量、IL-2、sIL-2R、TNF-α、sTNFR-I、Neopterin的浓度变化可以作为HAART治疗效果评价的重要指标.
Objective To explore the efficacy of anti-retroviral therapy in AIDS patients and its effect on immune function.Methods HAART therapy was used to treat 4 HIV / AIDS patients with severe immunocompromise.Results All patients underwent 4-week HIV replication Was significantly inhibited, the plasma viral load decreased by an average of 1.99log / ml (0.73 ~ 2.46log / ml), CD_8 ~ +, CD_4 ~ + cells and plasma IL-2 levels were significantly increased after 4 to 12 weeks, the increase The levels of sIL-2R, IL-6, TNF-α, sTNFR-I and Neopterin in the plasma decreased to normal levels or below after 4 to 12 weeks of treatment respectively Correlation analysis showed that the relationship between plasma viral load and serum levels of sIL-2R, IL-6, TNF-α, sTNFR and CD_4 ~ + cells and CD_8 ~ +, CD_3 ~ + cells and plasma IL- There was a significant positive correlation between sTNFR-I, Neopterin and sIL-2R, IL-6 and TNF-α. The number of CD_4 ~ + cells was positively correlated with plasma viral load, sIL-2R, sTNFR-I, Neopterin and IL-2 and sIL-2R.Conclusion The effect of antiviral therapy, viral replication and HAART treatment can rapidly and effectively inhibit the replication of HIV-1, correct the immune dysfunction and rebuild the immune function. The number of CD_4 ~ + cells in peripheral blood, plasma viral load, IL-2, sIL-2R , TNF-α, sTNFR-I, Neopterin concentration changes can be used as an important indicator of HAART treatment evaluation.