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目的探讨血清游离脂肪酸和2型糖尿病合并心血管自主神经病变(DCAN)的相关性。方法选取屯昌县人民医院收治的2型糖尿病合并心血管自主神经病变的患者为观察组,未合并的患者为对照组,再选取健康志愿者作为空白对照组。研究对象均测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)以及心血管自主神经功能。将糖尿病患者归为一个整体,以合并自主神经病变为因变量Y(有=1,无=0),以TC、TG、LDL-C、HDL-C和FFA为自变量进行Logistic多元回归分析。结果观察组患者各项指标检查结果和心血管自主神经各项检查结果与对照组相比,差异均有统计学意义(P<0.05),观察组与对照组的自变量TC、TG、LDL-C、HDL-C和FFA经Logistic多元回归分析,仅FFA比较差异有统计学意义(P<0.05)。结论血清FFA升高是2型糖尿病患者合并心血管自主神经病变的危险因素。
Objective To investigate the correlation between serum free fatty acid and type 2 diabetes with cardiovascular autonomic neuropathy (DCAN). Methods The patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy admitted to Tunchang County People’s Hospital were selected as the observation group and the unadjusted patients as the control group. The healthy volunteers were selected as the blank control group. All subjects were tested for triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), free fatty acid (FFA) and cardiovascular autonomic nerve function . The patients with diabetes were grouped as a whole, and the independent neuropathy was merged into the independent variable Y (with = 1, no = 0). Logistic multiple regression analysis was performed using TC, TG, LDL-C, HDL-C and FFA as independent variables. Results There were significant differences between the observation group and the control group (P <0.05). The independent variables TC, TG, LDL-C of the observation group and the control group were significantly different from those of the control group C, HDL-C and FFA by Logistic multiple regression analysis, only FFA difference was statistically significant (P <0.05). Conclusions Elevated serum FFA is a risk factor for type 2 diabetic patients with cardiovascular autonomic neuropathy.