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目的 :探讨端粒酶活性水平检测对癌性胸腔积液的诊断价值。方法 :采用Telomerase PCR ELISA法检测了 30例癌性胸腔积液及 2 1例良性胸腔积液的端粒酶活性水平 ,并与细胞学检查比较。结果 :癌性胸腔积液端粒酶活性阳性率 76 .6 % ,结核性胸腔积液 2 0 % ( 3/15 ) ,其他病因胸腔积液 0 % ( 0 /6 ) ,癌性胸腔积液端粒酶活性阳性率高于细胞学检测率 36 .6 % (P <0 .0 0 5 ) ,两者平行试验阳性率 83.3%。结论 :端粒酶活性检测可能成为诊断癌性胸腔积液的重要辅助手段。
Objective: To investigate the diagnostic value of telomerase activity in the diagnosis of pleural effusion. Methods: Telomerase PCR ELISA was used to detect telomerase activity in 30 cases of cancerous pleural effusion and 21 cases of benign pleural effusions, and compared with cytological examination. Results: The positive rate of telomerase activity in cancerous pleural effusion was 76.6%, 20% (3/15) in tuberculous pleural effusion, 0% (0/6) in other etiological pleural effusion, cancerous pleural effusion The positive rate of telomerase activity was higher than that of cytology (36.6%, P <0.05). The positive rate of telomerase activity was 83.3%. Conclusion: The detection of telomerase activity may be an important adjunct to diagnose malignant pleural effusion.