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目的观察泮托拉唑治疗上消化道出血的临床疗效及安全性。方法对临床证实238例上消化道出血患者随机双盲分为试验组120例和对照组118例,分别用泮托拉唑和奥美拉唑40mg,静脉注射2次/d,疗程3d;观察两组给药后48h及72h的临床症状改善,实验室指标或内镜下止血征象。结果总有效率试验组98.3%,对照组96.6%,两组比较差异无统计学意义(P>0.05)。无明显不良反应发生。结论注射用泮托拉唑治疗上消化道出血疗效显著,无明显毒副反应。
Objective To observe the clinical efficacy and safety of pantoprazole in the treatment of upper gastrointestinal bleeding. Methods A total of 238 cases of upper gastrointestinal bleeding were randomly divided into trial group (n = 120) and control group (n = 118), and were treated with pantoprazole and omeprazole 40 mg twice daily for 3 days respectively. The improvement of clinical symptoms at 48h and 72h after treatment in both groups showed signs of laboratory or endoscopic hemostasis. Results The total effective rate was 98.3% in the test group and 96.6% in the control group, with no significant difference between the two groups (P> 0.05). No significant adverse reactions occurred. Conclusion Pantoprazole injection for the treatment of upper gastrointestinal bleeding significant effect, no significant side effects.