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J.Am.Chem.Soc.2014,136,1230~1233二氟甲基类化合物由于其特殊性质在医药、农药和材料等领域具有重要的应用.该类化合物的合成主要是采用高活性的氟化试剂(如DAST,deoxofluor等)对羰基氟化来制备,但这些方法存在的一些弊端,如反应条件苛刻、氟化试剂昂贵有毒以及底物官能团兼容性窄等,限制了其广泛应用.近期中国科学院上海有机化学研究所张新刚课题组发展出一种以3-溴-3,3-二氟丙烯及其衍生物为氟源,在钯催化下对有机硼化合物(芳基硼酸、烯基硼酸、芳基硼酸酯、
J. Am. Chem. Soc. 2014, 136, 1230-1233 The difluoromethyl compounds have important applications in the fields of medicine, pesticides and materials because of their special properties. The synthesis of these compounds mainly uses highly active fluorine However, the disadvantages of these methods, such as harsh reaction conditions, expensive and toxic fluorinated reagents, and narrow compatibility of functional groups in the substrate, have limited their wide application. Recently, Zhang Xingang, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences has developed a group of 3-bromo-3,3-difluoropropene and its derivatives as a fluorine source, palladium catalyst for the organic boron compounds (aryl boronic acid, alkenyl boronic acid , Aryl boronic ester,