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目的观察双黄连粉针剂中绿原酸与氨苄青霉素在小儿静脉滴注时药物动力学的相互影响。方法临床治疗的呼吸系统感染小儿 ,在静脉滴注双黄连粉针剂(SHLP)60mg·kg-1或(和)氨苄青霉素钠(AMP)150mg·kg-1后采集不同时间段的尿样 ,用高效液相色谱法测定尿中绿原酸(CHA)和AMP浓度。结果两药合用后的24h排出率较单用时有明显下降(P<0.05),CHA和AMP的排出率分别由(51.7±15.6) %和(76.3±20.5) %下降至(42.1±12.2) %和(62.3±19.3) %,t1/2 分别由(3.44±1.14)h和(1.98±0.51)h增加至(4.33±1.38)h和(2.67±0.75)h ,增加明显(P<0.05) ,相应地Cl R 明显下降(P<0.05)。结论SHLP与AMP合用后体内CHA和AMP排出下降。
Objective To observe the interaction between chlorogenic acid and ampicillin in shuanghuanglian injection in pediatric intravenous drip. Methods Children with respiratory diseases undergoing clinical treatment were enrolled in this study. Urine samples of different time periods were collected after intravenous instillation of 60 mg · kg-1 Shuanghuanglian injection (SHLP) or 150 mg · kg-1 of ampicillin (AMP) Determination of urinary chlorogenic acid (CHA) and AMP by high performance liquid chromatography. Results Compared with the single administration, the excretion rates of CHA and AMP decreased significantly from (51.7 ± 15.6)% and (76.3 ± 20.5)% to (42.1 ± 12.2)%, respectively (62.3 ± 19.3)% and t1 / 2 increased from (3.44 ± 1.14) h and (1.98 ± 0.51) h to (4.33 ± 1.38) h and (2.67 ± 0.75) h, respectively Accordingly, Cl R decreased significantly (P <0.05). Conclusions After combination of SHLP with AMP, CHA and AMP excretion decreased.