给小鼠、大鼠和豚鼠静脉注射大剂量BCG,可引起T细胞的无应答性,但皮内感染则不引起。这种无应答性,可能是由于抑制细胞的存在。最近报道,用BCG静脉感染小鼠,诱导T抑制细胞,通过释放可溶性非特异性抑制因子,能够抑制促分裂原诱导IL-2产生。试验结果提示:在培养物中加入外源性IL-2制剂可逆转这种无应答性。 Intravenous injection of large doses of BCG to mice, rats and guinea pigs can cause an unresponsiveness of T cells but not intradermal infection. This non-responsiveness may be due to the inhibition of the presence of cells. Recently, it has been reported that intravenous inoculation of mice with BCG induces T-suppressor cells and inhibits mitogen-induced IL-2 production by releasing soluble nonspecific suppressors. The results suggest that adding exogenous IL-2 to culture reverses this non-responsiveness.