目的了解代谢综合征患者合并外周动脉疾病(PAD)的发病情况,以及代谢综合征与PAD相关危险因素的关系。方法住院和门诊2115例代谢综合征患者,年龄32-91(67．6±5．1)岁,男1132例,女983例。收集相关的临床资料和进行踝臂指数测定,踝臂指数小于0．9诊断有PAD,并进行PAD相关临床资料的分析和统计学处理。结果代谢综合征合并PAD的患者为476例,总的发病率为22．5％。男性246例,占代谢综合征合并PAD患者的51．68％;女性则为230例(48．32％);平均年龄分别为71．3±9．4和71．2±8．2岁。代谢综合征患者随着年龄的增长患PAD的危险性增高,OR值为1．069,95％可信区间为1．054-1．083,而且与性别、吸烟、糖尿病、冠心病和缺血性卒中有相关性(均P<0．05)。女性代谢综合征合并PAD患者与非PAD患者相比,血尿素氮,血肌酐和血尿酸的水平明显较高(P<0．05)。结论代谢综合征患者易合并PAD,并随着年龄的增长,相关危险因素的增加,代谢综合征患者更易患PAD。女性代谢综合征合并PAD患者与非PAD患者相比肾功能减弱明显。 Objective To investigate the incidence of PAD in patients with metabolic syndrome and the relationship between metabolic syndrome and PAD-related risk factors. Methods A total of 2115 patients with metabolic syndrome who were hospitalized and outpatient, aged 32-91 (67.6 ± 5.1) years, including 1132 males and 983 females. Relevant clinical data were collected and the ankle-brachial index was measured. The ankle-brachial index of less than 0.9 was diagnosed as PAD, and the clinical data of PAD were analyzed and statistically analyzed. Results 476 patients with metabolic syndrome complicated with PAD had a total incidence of 22.5%. There were 246 males, accounting for 51.68% of patients with metabolic syndrome complicated with PAD and 230 females (48.32%) with average age of 71.3 ± 9.4 and 71.2 ± 8.2 years, respectively. Patients with metabolic syndrome had a higher risk of developing PAD with age, with a OR of 1.069 and a 95% confidence interval of 1.054 to 1.083, which was associated with gender, smoking, diabetes, coronary heart disease, and ischemia Sexual stroke were related (all P <0.05). Blood urea nitrogen, serum creatinine and serum uric acid were significantly higher in female patients with metabolic syndrome and PAD compared with non-PAD patients (P <0.05). Conclusion Metabolic syndrome patients with easy to merge PAD, and with age, related risk factors increased, metabolic syndrome patients are more susceptible to PAD. Metabolic syndrome in women with PAD compared with non-PAD patients significantly reduced renal function.