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垂体促甲状腺激素(TSH)的合成与分泌受两种相反的因素调节,下丘脑分泌的促甲状腺激素释放激素(TRH)能促进TSH的合成及分泌,而血清T_4、T_3通过负反馈效应抑制上述作用,换言之,TSH对TRH的反应程度与甲状腺功能有直接关系,因此,垂体TSH对外源性TRH的反应程度可作为T_4、T_3反馈作用的一种指征。本文作者指出,过去采用的TRH兴奋试验有两点不足,一是经TRH兴奋后,所测得的TSH值仅反应了单时相分泌水平,
The synthesis and secretion of pituitary thyroid stimulating hormone (TSH) are regulated by two opposite factors. The thyroid-stimulated hormone releasing hormone (TRH) secreted by the hypothalamus can promote the synthesis and secretion of TSH, while the serum T_4 and T_3 inhibit the above mentioned In other words, the response of TSH to TRH is directly related to the thyroid function. Therefore, the degree of response of pituitary TSH to exogenous TRH can be used as an indication of the feedback of T_4 and T_3. The authors point out that TRH excitement test used in the past has two deficiencies, one is excited by TRH, the measured TSH value only reflects the level of single-phase secretion,