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目的 探讨急性脑血管病与 β-Ap的量变关系 ,测定其血浆中含量的临床意义。 方法 采用平衡饱和放射免疫法测定脑出血病 36例、脑梗死组 45例 ,健康对照组 2 0例 ,测定其血浆中 β -淀粉样蛋白的含量。结果 脑出血组 β -Ap含量 (1.6 2 72± 0 .4190 )ng/ml;脑梗死组 :β -Ap含量(1.7117± 0 .3 5 70 )ng/ml;健康对照组 :(1.2 10 8± 0 .3373)ng/ml。脑出血组与脑梗死组之间无显著性差异 ,但两组均高于正常对照组 ,并且有显著性差异 (P <0 .0 5 )。结论 急性脑血管病患者 β -Ap水平明显高于健康对照组 ,并且随病情加重其含量有增高趋势 ,一定程度上说明脑血管病的严重程度
Objective To investigate the relationship between the quantity of β-Ap in patients with acute cerebrovascular disease and the clinical significance of its content in plasma. Methods Thirty - six patients with cerebral hemorrhage, 45 cerebral infarction patients and 20 healthy controls were measured by balanced saturated radioimmunoassay. The content of β - amyloid in plasma was measured. Results The levels of β -Ap in cerebral hemorrhage group were (1.6 2 72 ± 0. 4190) ng / ml; those in cerebral infarction group were (1.7117 ± 0.3570) ng / ml; ± 0.3373) ng / ml. No significant difference between cerebral hemorrhage group and cerebral infarction group, but both groups were higher than the normal control group, and there was a significant difference (P <0.05). Conclusions The level of β -Ap in patients with acute cerebrovascular disease is significantly higher than that in healthy controls, and the content of β -Ap increases with the increase of illness, to a certain extent, the severity of cerebrovascular disease