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目的 :比较恩丹西酮、恩丹西酮 +地塞米松、恩丹西酮 +地塞米松 +国产甲孕酮 (倍恩胶囊 )三种止吐方案预防化疗消化道反应的疗效。方法 :以中等剂量顺铂或阿霉素为主化疗的患者 90例 ,随机分成三组 ,每组 30例 ,分别使用上述止吐方案 ,观察其预防化疗消化道反应的效果。结果 :对于呕吐 ,单用恩丹西酮、恩丹西酮 +地塞米松、恩丹西酮 +地塞米松+倍恩胶囊三个方案的有效率相近 ,分别为 80 %、87%、90 % ;对于恶心 ,三个方案的有效率分别为 6 3%、80 %、90 % ,差别具有显著性 (χ2 =6 .3,P <0 0 5 ) ;对于食欲不振 ,三个方案的有效率分别为 17%、5 3%、80 % ,有极显著差异 (χ2 =2 4 .2 7,P <0 0 0 5 )。结论 :单独使用恩丹西酮不足以完全预防化疗消化道反应 ,加用地塞米松后效果有所提高 ,但以恩丹西酮 +地塞米松 +倍恩胶囊最好 ,特别是预防化疗恶心和食欲不振明显优于单用恩丹西酮或恩丹西酮 +地塞米松
OBJECTIVE: To compare the efficacy of ondansetron, ondansetron + dexamethasone, ondansetron + dexamethasone + domestic progesterone (Bene Capsules) in the prevention of gastrointestinal reactions. Methods: 90 patients with moderate dose of cisplatin or doxorubicin-based chemotherapy were randomly divided into three groups (n = 30 in each group). The above antiemetic solutions were used respectively to observe the effect of preventing chemotherapy-induced digestive tract reaction. Results: For vomiting alone, ondansetron, ondansetron + dexamethasone, ondansetron + dexamethasone + bene capsule three programs of the efficiency were similar, respectively, 80%, 87%, 90 %; For nausea, the effectiveness of the three programs were 63%, 80%, 90%, the difference was significant (χ2 = 6.3, P <0 05); for loss of appetite, the three programs have The efficiencies were 17%, 53% and 80%, respectively, with a significant difference (χ2 = 24.27, P <0.05). Conclusion: Ondansetron alone is not enough to completely prevent the chemotherapy of digestive tract reaction, with dexamethasone after the effect has been increased, but with ondansetron + dexamethasone + times capsule best, especially to prevent chemotherapy and nausea and Loss of appetite was significantly better than ondansetron alone or ondansetron + dexamethasone