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实验比较了甲状腺功能亢进(甲亢)、甲状腺功能减退(甲减)和对照组大鼠血浆中心钠素(ANF)、血管紧张素Ⅱ(ATⅡ)和醛固酮(ALD)的相关关系。结果表明甲亢大鼠血浆中ATⅡ和ALD明显高于对照组(P<0.05),而ANF升高的更为明显(P<0.01)。相反甲减大鼠血浆ALD明显低于对照组(P<0.05),而ATⅡ和ANF则降低的更为显著(P<0.01),结果提示在甲状腺功能异常的病理过程中,血浆ATⅡ和ALD首先发生变化,从而引起血浆ANE释放量发生变化来调节机体的相对平衡。
The relationship between hyperthyroidism (hyperthyroidism), hypothyroidism (hypothyroidism), and plasma NPA (ANF), angiotensin II (ATII), and aldosterone (ALD) in the control group was compared. The results showed that the levels of AT II and ALD in plasma of hyperthyroidism rats were significantly higher than those in the control group (P <0.05), while the increase in ANF was more pronounced (P <0.01). On the contrary, the plasma ALD in rats with hypothyroidism was significantly lower than that in the control group (P<0.05), but the ATII and ANF decreased more significantly (P<0.01). The results suggest that plasma ATII and ALD are the first to be pathological in the process of abnormal thyroid function. Changes occur, causing changes in plasma ANE release to regulate the body’s relative balance.