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目的分析新发糖尿病患者血清超敏C反应蛋白(hs-CRP)水平及其影响因素,为糖尿病的病因学研究及早期防治提供依据。方法以2009年6月至2012年6月在北京中日友好医院行健康体检的人群中首次发现空腹血糖(FPG)≥7.0mmol/L且未服用过降糖、降压和调血脂药物者536例为研究对象,比较不同性别新发糖尿病患者的hs-CRP水平分布情况及影响因素。结果不同性别新发糖尿病患者hs-CRP水平分布情况比较,差异有统计学意义(P<0.05)。男性糖尿病患者腰围、腰臀比、舒张压和吸烟比例均高于女性糖尿病患者,而高密度脂蛋白胆固醇(HDL-C)水平低于女性糖尿病患者,差异均有统计学意义(P<0.05)。年龄、性别、体质指数(BMI)、腰围、FPG、甘油三酯(TG)是影响糖尿病患者hs-CRP水平的因素。女性糖尿病患者的腰围、BMI的比值比(OR值)均高于男性糖尿病患者(P<0.01)。结论 hs-CRP水平受多种因素影响,与腹型肥胖密切相关。
Objective To analyze the serum levels of hs-CRP and its influencing factors in patients with newly diagnosed diabetes mellitus, and provide evidences for the etiological study and early prevention and treatment of diabetes mellitus. Methods From June 2009 to June 2012, we found for the first time that the patients with fasting plasma glucose (FPG) ≥7.0mmol / L and those who had not taken hypoglycemic, antihypertensive and lipid-lowering drugs were in the group of Beijing-Japan Friendship Hospital in Beijing. Cases for the study, the comparison of hs-CRP levels in different genders of new onset diabetes mellitus and its influencing factors. Results The distribution of hs-CRP in patients with different genders of newly diagnosed diabetes was significantly different (P <0.05). The waistline, waist-hip ratio, diastolic blood pressure and smoking rate in male patients with diabetes were higher than those in female patients with diabetes, while the levels of high-density lipoprotein cholesterol (HDL-C) were lower than those in female patients with diabetes (P <0.05) . Age, sex, body mass index (BMI), waist circumference, FPG, triglyceride (TG) are the factors influencing hs-CRP level in diabetic patients. The waist circumference and BMI of women with diabetes were higher than those of men with diabetes (P <0.01). Conclusion The hs-CRP level is influenced by many factors, which is closely related to abdominal obesity.