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目的 分析涎腺透明细胞癌 (CCC)的临床病理特征。方法 对上海第二医科大学附属第九人民医院口腔医学院口腔病理科在 1985年 1月至 2 0 0 4年 5月期间诊断为涎腺肿瘤的病例进行回顾性分析 ,确诊了 10例CCC ,并进行临床病理分析及随访。结果 10例CCC部位 :7例腭部、1例舌根、1例磨牙后区、1例口底 ,男、女性各 5例 ,平均年龄为 5 5岁。光镜下肿瘤主要由排列成小梁状、带状、巢状、团块状的透明细胞及少量嗜酸性细胞组成 ,细胞周围常有玻璃样变物包绕。免疫组化 :10例肿瘤细胞EMA、CK8呈阳性表达 ,5例CK18呈阳性表达 ,2例CKHMW呈阳性表达 ,CK10 / 13、S 10 0、SMA、Calponin均呈阴性表达。 8例随访患者术后均无复发或转移。结论 CCC是一种独立的、低度恶性的涎腺肿瘤 ,好发于小涎腺 ,肿瘤可能来源于闰管储备细胞
Objective To analyze the clinicopathological features of salivary clear cell carcinoma (CCC). Methods The cases diagnosed as salivary gland tumors during the period from January 1985 to May 2004 in Department of Stomatology, The 9th People’s Hospital of Shanghai Second Medical University were retrospectively analyzed. Ten cases of CCC were confirmed, And clinical and pathological analysis and follow-up. Results 10 cases of CCC site: palatal 7 cases, 1 tongue base, 1 case of posterior molar teeth, 1 case of mouth, 5 males and 5 females, mean age was 55 years. Light microscopic tumor consists of arranged in trabecular, ribbon, nests, clumps of transparent cells and a small amount of eosinophils, cells often surrounded by glassy material. Immunohistochemistry: EMA and CK8 were positive in 10 cases, CK18 was positive in 5 cases, CKHMW was positive in 2 cases, negative was CK10 / 13, S 10 0, SMA and Calponin respectively. No recurrence or metastasis was found in 8 patients after follow-up. Conclusion CCC is an independent, low-grade salivary gland tumor that occurs in the small salivary gland. The tumor may originate from the intercalary canal reserve cells