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白色或类白色结晶性粉末,无臭、味苦。溶于水、乙醇,微溶于丙酮,不溶于乙醚。本品国外于1975年合成,1981年日本首次上市。经药理作用研究,认为本品主要作用于β_2受体,对心脏兴奋作用较轻,对支气管平滑肌具有强而持久的扩张作用,为一新的疗效显著的长效选择性β_2受体兴奋剂。国内经东北制药总厂、上海第十七制药厂等单位研制成功,经临床验证表明,本品确有良好的平喘疗效,且作用较持久。药理作用:经动物试验证明,本品扩张气管作用较异丙肾上腺素及喘通为强且持久。本品2×10~(-4)g/ml浓度能弛缓豚鼠离体气管平滑肌,其作用是喘通的2～10倍,而对心脏的不良作用仅是异丙肾上腺素的1/1000,舒喘宁的1/100。作用时间较异丙肾上腺素和舒喘宁长10倍多。以本品5、10、20、30mg/kg对豚鼠灌胃,给药后1、2、4小时内均有明显的止喘作用。当剂量为3mg/kg时平喘作用很弱,说明本品的平喘作用强度和持续时间与剂量大小有关,
White or almost white crystalline powder, odorless, bitter taste. Soluble in water, ethanol, slightly soluble in acetone, insoluble in ether. This product was synthesized abroad in 1975, Japan first listed in 1981. The pharmacological effects of the study, that the main role of β 2 receptors on the product, the role of the heart less light on the bronchial smooth muscle has a strong and lasting expansion of a new significant effect of long-acting selective β 2 receptor agonists. China’s Northeast Pharmaceutical Factory, the seventeenth Shanghai Pharmaceutical Factory and other units successfully developed, clinically proven that this product does have a good asthma efficacy, and the role of long-lasting. Pharmacological effects: animal experiments show that the expansion of the tracheal products than isoproterenol and asthma is strong and lasting. This product 2 × 10 ~ (-4) g / ml concentration can relax guinea pig tracheal smooth muscle, the role of asthma 2 to 10 times, while the adverse effects on the heart is only 1/1000 of isoprenaline, Salbutamol 1/100. The role of time than isoproterenol and salbutamol longer than 10 times. To the goods 5,10,20,30 mg / kg guinea pig gavage, 1,2,4 hours after administration have significant anti-asthmatic effect. When the dose of 3mg / kg antiasthmatic effect is very weak, indicating that the product of the antiasthmatic effect intensity and duration of the dose size,