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目的探讨慢性脑供血不足(CCCI)患者脑认知功能损害与 IL-1β蛋白的关系及脑血流减少的分布特点。方法 52名CCCI 患者根据 MMSE 评分分为单纯的 CCCI 组和 CCCI 伴认知功能障碍组及38名正常对照组,采用放免法测定 IL-1β蛋白水平和 ECT 测定脑血流,并对三组进行比较。结果 CCCI 伴认知功能障碍组 IL-1β蛋白表达较其他两组明显增加,差异有显著的统计学意义(P<0.01);单纯的 CCCI 组与对照组相比差异有统计学意义(P<0.05);CCCI 伴认知功能障碍组较单纯的 CCCI 组γCBF 在额叶、颞叶、基底节脑血流减少更显著,有统计学意义(P<0.05)。结论 CCCI 的认知损害的机制与炎性细胞因子 IL-1β蛋白的过度持续表达及脑血流在特定脑区(额叶、颞叶、基底节)显著降低有关。
Objective To investigate the relationship between brain cognitive impairment and IL-1β protein and the distribution of cerebral blood flow in patients with chronic cerebral insufficiency (CCCI). Methods Fifty-two patients with CCCI were divided into three groups: CCCI group, CCCI with cognitive impairment group and 38 normal control group according to MMSE score. The levels of IL-1β protein and ECT were determined by radioimmunoassay, Compare Results The expression of IL-1β protein in CCCI with cognitive impairment group was significantly higher than that in other two groups (P <0.01). The difference between CCCI group and control group was statistically significant (P < 0.05). Compared with pure CCCI group, the CCC with cognitive impairment in CCCI group showed more significant reduction of blood flow in the frontal lobe, temporal lobe and basal ganglia, with statistical significance (P <0.05). Conclusion The mechanism of cognitive impairment in CCCI is related to the overexpression of inflammatory cytokines IL-1β and the significant decrease of cerebral blood flow in specific brain regions (frontal lobe, temporal lobe, basal ganglia).