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目的探讨大肠癌伴随肝转移患者的纤维蛋白原降解产物(FDP)和D-二聚体(D-D)检验指标的诊断价值。方法选择2012年6月至2013年6月收治的大肠癌患者80例,分为远处转移组(n=50)和无远处转移组(n=30),选择同期健康体检者80例作为对照组,各组均进行血清FDP和D-二聚体的检测。结果肿瘤组患者的FDP和D-二聚体表达值明显高于对照组,差异有统计学意义(P<0.05)。转移组患者FDP和D-二聚体表达值明显高于无转移组(P<0.05)。转移组患者的FDP和D-二聚体表达阳性率明显高于无转移组,差异有统计学意义(P<0.05)。多因素非条件Logistic回归分析结果显示,FDP和D-二聚体为肝转移的主要独立危险因素(P<0.05)。结论血液高凝状态是促进肿瘤转移的重要条件,高凝状态影响恶性肿瘤的生长和转移,FDP和D-二聚体可作为有效预测大肠癌肝转移的生物学指标。
Objective To investigate the diagnostic value of fibrinogen degradation product (FDP) and D-dimer (D-D) in patients with liver cancer with colorectal cancer. Methods Eighty patients with colorectal cancer who were admitted to our hospital from June 2012 to June 2013 were divided into two groups: distant metastasis group (n = 50) and non-distant metastasis group (n = 30) Control group, each group were tested for serum FDP and D-dimer. Results The expression of FDP and D-dimer in the tumor group was significantly higher than that in the control group (P <0.05). The expression of FDP and D-dimer in metastasis group was significantly higher than that in non-metastasis group (P <0.05). The positive rate of FDP and D-dimer expression in metastasis group was significantly higher than that in non-metastasis group (P <0.05). Multivariate non-conditional logistic regression analysis showed that FDP and D-dimer were the main independent risk factors for liver metastasis (P <0.05). Conclusion Hypercoagulable state of blood is an important condition to promote tumor metastasis. Hypercoagulable state affects the growth and metastasis of malignant tumor. FDP and D-dimer can be used as biomarkers to predict liver metastasis of colorectal cancer effectively.