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糖尿病肾病( DN)是糖尿病的主要并发症之一，也是引起终末期肾病和糖尿病患者死亡的常见原因。多种机制参与DN的发生、发展，如糖、脂代谢紊乱、血流动力学异常、细胞因子、氧化应激等。 p38丝裂原活化蛋白激酶( MAPK)是MAPKs超家族的重要成员，是细胞信号通路的交汇点，在调节细胞代谢、分化、增殖、凋亡等方面具有重要作用。该通路在DN时被激活，通过影响细胞外基质形成、促进细胞凋亡、影响细胞因子的产生等促进DN的发生和发展。因此，明确p38 MAPK在DN中的作用具有重要的临床意义。“,”Diabetic nephropathy( DN) is one of the most common chronic complications of diabetes mel-litus,and is the leading cause of end-stage renal disease. Many mechanisms are involved in the development and progress of DN,such as sugar and lipid metabolism disorders,hemodynamic dysfunctions,cytokines and oxidative stress. p38 mitogen-activited protein kinase( MAPK) is the intersection of cell signaling pathways, which is an important member of the MAPKs superfamily, plays an important role in the regulation of cell metabolism,differentiation,proliferation,and apoptosis. It can be activated in DN promoting the development and progress of DN by affecting the formation of extracellular matrix,promoting apopsis,and influencing the expression of cytokines. Therefore,making clear the effects of p38 MAPK in DN is of great clinical signifi-cance.