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目的:研究CXCR4和HER-2在上皮性卵巢肿瘤中的表达情况及其相关性。方法:应用免疫组织化学方法检测30例浆液性和粘液性卵巢癌、10例浆液性和粘液性卵巢囊腺瘤、5例卵巢癌盆腔腹膜转移灶及8例正常卵巢组织中CXCR4和HER-2的表达情况。结果:CXCR4在卵巢恶性肿瘤原发灶及转移灶中均呈高表达,阳性率分别为63.3%,80%,明显高于其在正常卵巢组织及卵巢良性肿瘤中的表达。HER-2在卵巢恶性肿瘤及转移灶中均呈高表达,阳性率分别为70%,80%,明显高于正常卵巢组织及卵巢良性肿瘤。CX-CR4、HER-2在卵巢囊腺癌中的表达呈显著正相关(P<0.001)。结论:CXCR4、HER-2在卵巢上皮性囊腺癌及转移灶中的阳性表达率较高,且两者的表达呈显著性正相关。提示了CXCR4、HER-2在上皮性卵巢囊腺癌的发生和转移中起着重要作用。
Objective: To investigate the expression of CXCR4 and HER-2 in epithelial ovarian tumors and their correlation. Methods: The expressions of CXCR4 and HER-2 in 30 cases of serous and mucinous ovarian cancer, 10 cases of serous and mucinous ovarian cystadenoma, 5 cases of pelvic peritoneal metastasis of ovarian cancer and 8 cases of normal ovarian tissue were detected by immunohistochemistry. The expression of the situation. Results: CXCR4 was highly expressed in primary and metastatic ovarian cancer, the positive rates were 63.3% and 80%, respectively, which were significantly higher than those in normal ovarian tissues and benign ovarian tumors. HER-2 was highly expressed in malignant ovarian tumors and metastases, the positive rates were 70% and 80%, respectively, which were significantly higher than those in normal ovarian tissues and benign ovarian tumors. The expressions of CXCR4 and HER-2 in ovarian cystadenocarcinoma were significantly and positively correlated (P <0.001). Conclusion: The positive rates of CXCR4 and HER-2 in ovarian epithelial cystadenocarcinoma and metastasis are high, and the expressions of both are positively correlated. It is suggested that CXCR4 plays an important role in the occurrence and metastasis of epithelial ovarian cystadenocarcinoma.