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1853年Gerhardt合成阿斯匹林(ASA)用于临床迄今已百余年,由于可靠的解热镇痛抗炎作用,现仍在临床治疗中占重要地位,是世界上应用普遍、用量最大的药物之一。1971年Smith和Willis证明ASA抑制前列腺素类(PGS)的合成,可能影响血栓形成和循环功能,因而临床广泛试用于冠心病心肌梗塞及其他血栓栓塞性疾病的防治,本文拟就此方面作一回顾。
In 1853, Gerhardt Synthetic Aspirin (ASA) has been used clinically for more than 100 years so far. Due to its reliable antipyretic, analgesic and anti-inflammatory effects, Gerhardt is still in clinical treatment and occupies an important position in the world. It is the most commonly used and most widely used One of the medicines. In 1971, Smith and Willis demonstrated that ASA inhibits the synthesis of prostaglandins (PGS) and may affect thrombosis and circulatory function. Therefore, ASA is widely used in the prevention and treatment of coronary heart disease and other thromboembolic diseases. .