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目的:研究结直肠肿瘤病人粪便短链脂肪酸(SCFA)的影响因素及其与肿瘤细胞凋亡的关系。方法:收集首次确诊拟行根治手术的结直肠癌病人的资料,采集描述性指标(年龄、性别、肿瘤家族史、烟酒史)、肿瘤指标(大小、临床分期、局部和远处转移)、营养相关指标(身高、体重、血红蛋白、清蛋白)和膳食摄入情况。检测肿瘤细胞凋亡情况和粪便SCFA水平。结果:共收集35例病人资料。所有病人均能保证每天摄入蔬菜,但粗粮、奶和酸奶制品、水果摄入量的摄入频次较推荐量明显不足。年龄、性别、肿瘤部位、临床分期、蔬菜、水果和粗粮摄入频数、饮酒、肿瘤家族史等,未对病人粪便SCFA水平产生明显影响。酸奶摄入≥1次/周的结直肠肿瘤病人较<1次/周者粪便丁酸含量明显升高。吸烟则明显降低粪便丁酸水平。结论:吸烟可降低结直肠肿瘤病人粪丁酸含量,酸奶摄入≥1次/周者,可升高粪丁酸含量。在不吸烟和酸奶摄入≥1次/周的病人中,有增加肿瘤细胞凋亡的趋势。
Objective: To study the influential factors of stool short chain fatty acid (SCFA) in colorectal cancer and its relationship with tumor cell apoptosis. Methods: Data of colorectal cancer patients who underwent radical surgery were collected for the first time. Descriptive indexes (age, gender, family history of cancer, history of alcohol and tobacco), tumor markers (size, clinical stage, local and distant metastasis) Nutrition related indicators (height, weight, hemoglobin, albumin) and dietary intake. Tumor cell apoptosis and stool SCFA levels were detected. Results: A total of 35 patients were collected. All patients can ensure daily intake of vegetables, but coarse grains, milk and yogurt products, the intake of fruit intake was significantly less than the recommended amount. Age, sex, tumor location, clinical staging, frequency of intake of vegetables, fruits and coarse grains, alcohol consumption, family history of the cancer did not significantly affect SCFA levels in the patient’s feces. Yogurt intake ≥ 1 times / week colorectal cancer patients than <1 times / week was significantly increased fecal butyric acid. Smoking significantly reduced fecal butyric acid levels. Conclusion: Smoking can reduce the concentration of fecal butyric acid in patients with colorectal neoplasms. The intake of yogurt ≥ 1 time per week can increase the content of feces butyric acid. In non-smoking and yogurt intake ≥ 1 times / week patients, there is a trend of increasing tumor cell apoptosis.