肿瘤、外伤、缺血性卒中等中枢神经系统疾病均伴有脑水肿的发生,主要分为血管源性和细胞毒性脑水肿,大多数病理过程中两类脑水肿同时存在。但目前尚缺乏普遍有效、副作用少的治疗脑水肿药物。例如甘露醇通过渗透性脱水降低脑组织含水量,但对血脑屏障破坏的病灶,甘露醇进入病灶 Tumors, trauma, ischemic stroke and other central nervous system diseases are associated with cerebral edema, mainly divided into vascular and cytotoxic brain edema, most of the two types of brain edema in the pathological process exist. However, there is a lack of commonly used drugs for the treatment of cerebral edema which are generally effective and have few side effects. For example, mannitol reduces the water content of brain tissue through osmotic dehydration, but the lesions of the blood-brain barrier and mannitol enter the lesions