左卡尼汀联合促红细胞生成素治疗血液透析患者肾性贫血的Meta分析

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目的研究左卡尼汀联合促红细胞生成素治疗肾性贫血的临床效果。方法 100例肾病患者随机分为对照组和观察组,各50例。对照组采用常规促红细胞生成素进行治疗,观察组则在常规治疗的基础上采用左卡尼汀治疗。观察两组患者治疗后的外周血血红蛋白(Hb)、红细胞压积(Hct)指标以及血压变化等情况,判定药物疗效。结果经过临床干预后,两组患者的症状均有明显好转,在治疗期间均无不良反应出现。对比发现,观察组患者的治疗效果比对照组更加明显,15 d的治疗期后,与对照组相患者相比有了明显改善,治疗周期较短,比较差异有统计学意义(P<0.05);经过对两组患者进行满意度调查,观察组患者的满意率为94.0%,对照组为72.0%,两组比较差异有统计学意义(P<0.05)。结论左卡尼汀联合促红细胞生成素比常规药物的治疗效果更加有效,值得临床推广。 Objective To study the clinical effect of levocarnitine combined with erythropoietin in the treatment of renal anemia. Methods 100 cases of nephropathy were randomly divided into control group and observation group, 50 cases each. The control group was treated with conventional erythropoietin, while the observation group was treated with levocarnitine on the basis of routine treatment. After treatment, the hemoglobin (Hb), hematocrit (Hct) and blood pressure were observed to determine the efficacy of the drug. Results After clinical intervention, the symptoms of both groups were significantly improved, and no adverse reactions occurred during the treatment. Compared with the control group, the treatment effect of the observation group was more obvious than that of the control group. After the 15-day treatment, the treatment group showed a significant improvement compared with the control group, the treatment period was shorter, the difference was statistically significant (P <0.05) After the satisfaction survey of two groups of patients, the satisfaction rate of patients in the observation group was 94.0% and that of the control group was 72.0%. There was significant difference between the two groups (P <0.05). Conclusion L-carnitine combined with erythropoietin is more effective than conventional drugs in treatment, which is worthy of clinical promotion.
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