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Sprague-Dawley(SD)大鼠(雄性)烫伤(相当于体表面积的20%,Ⅲ°)后30分钟组和烫伤后2小时组,其肝脏线粒体呼吸控制率(RCR)均比固定对照组和正常对照组高,差异显著;且烫伤后30分钟组肝脏线粒体氧化磷酸化效率(ADP/O)比固定对照组高,差异亦显著。此外从对32只雄性Wistar大鼠的测定结果中,也发现烫伤后30分钟组的肝脏线粒体RCR比固定对照组高,差异显著。SD大鼠烫伤后4小时组,其ADP/O比固定对照组低,差异十分显著;而RCR已接近正常。(大鼠肝脏线粒体活性测定时,均以琥珀酸盐为氧化底物)。说明大鼠烫伤后早期肝脏线粒体氧化磷酸化曾有偶联增强的时相。
Sprague-Dawley (SD) rats (male) scald (equivalent to 20% of body surface area, III°) 30 min after the group and 2 h after scald, their liver mitochondrial respiratory control rate (RCR) were both higher than those of the fixed control group and The normal control group was high and the difference was significant. The oxidative phosphorylation of liver mitochondria (ADP/O) was higher than that of the control group at 30 minutes after scald, and the difference was also significant. In addition, from the results of the determination of 32 male Wistar rats, it was also found that the liver mitochondrial RCR at 30 minutes after scald was higher than the fixed control group, and the difference was significant. In the SD rats at 4 hours after scald, the ADP/O was lower than that in the fixed control group, and the difference was very significant; however, the RCR was nearly normal. (Succinate was used as the oxidative substrate for the determination of rat liver mitochondrial activity). It was demonstrated that the oxidative phosphorylation of liver mitochondria in the early stage of scald injury in rats had an increased coupling phase.