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目的探讨口服榄香烯联合TF化疗方案(紫杉醇+亚叶酸钙/氟尿嘧啶)治疗中晚期食管癌的临床疗效。方法选取2012年11月—2015年11月盐城市第二人民医院收治的中晚期食管癌患者44例,按照入院顺序分为对照组与试验组,各22例。对照组给予紫杉醇+亚叶酸钙/氟尿嘧啶静脉化疗,试验组在此基础上加用榄香烯治疗。比较两组患者临床疗效、毒副作用发生率、生活质量总改善率。结果两组患者总有效率、毒副作用发生率比较,差异无统计学意义(P>0.05)。试验组生活质量总改善率高于对照组,差异有统计学意义(P<0.05)。结论口服榄香烯联合TF化疗方案治疗中晚期食管癌的临床疗效确切,安全性高,可有效改善患者生活质量。
Objective To investigate the clinical efficacy of oral elemene combined with TF chemotherapy (paclitaxel + leucovorin / fluorouracil) in the treatment of advanced esophageal cancer. Methods Forty-four patients with advanced esophageal cancer treated in Yancheng Second People’s Hospital from November 2012 to November 2015 were selected and divided into control group and trial group according to admission sequence, with 22 cases in each group. Control group was given paclitaxel + leucovorin / fluorouracil intravenous chemotherapy, the experimental group on this basis plus elemene treatment. The clinical efficacy, the incidence of toxic and side effects, and the overall quality of life improvement were compared between the two groups. Results The total effective rate of the two groups of patients, the incidence of toxic and side effects, the difference was not statistically significant (P> 0.05). The total quality of life of the experimental group was significantly higher than that of the control group (P <0.05). Conclusion The combination of oral elemene combined with TF chemotherapy in the treatment of advanced esophageal cancer has definite curative effect and high safety. It can effectively improve the quality of life of patients.