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目的:利用快速液相-三重串联四级杆质谱(RRLC/MS/MS)技术鉴定清毒安肾胶囊中的化学成分。方法:用Agilent ZORBAX SB-C18色谱柱,以乙腈-0.1%甲酸水溶液为流动相进行梯度洗脱,电喷雾质谱在线检测(正负离子两种模式、MS和MS/MS两种扫描方式)。结果:鉴定了清毒安肾胶囊中32个化学成分。结论:该研究为阐明清毒安肾胶囊的化学物质基础提供了依据。
OBJECTIVE: To identify the chemical constituents of Chunduankang Capsule by rapid liquid chromatography-triple quadrupole mass spectrometry (RRLC / MS / MS). METHODS: The gradient was eluted with an Agilent ZORBAX SB-C18 column using a mobile phase of acetonitrile-0.1% formic acid as mobile phase. The electrospray ionization mass spectrometry was performed online (positive and negative ion modes, MS and MS / MS). Results: 32 chemical constituents of Qingduanling Capsule were identified. Conclusion: This study provides the basis for elucidating the chemical substance foundation of Qingdu Anxian Capsule.