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目的探究单核苷酸多态性rs1885068不同基因型与不同卒中亚型长期预后的相关性。方法采用前瞻性队列研究设计。通过对不同卒中亚型患者约4.5年的随访,记录患者卒中复发和全因死亡情况,分析单核苷酸多态性rs1885068不同基因型与卒中患者长期预后的相关性。使用聚合酶链式反应-连接酶检测反应(PCR-LDR)检测卒中患者单核苷酸多态性rs1885068的基因型。结果对不同卒中亚型患者随访后发现,单核苷酸多态性rs1885068与腔隙性脑梗死患者的长期预后呈显著相关(log-rank P=0.034)。Cox比例风险模型校正年龄、性别、高血压、糖尿病、吸烟史、饮酒史后,结果显示单核苷酸多态性rs1885068 T等位基因增加脑卒中复发和全因死亡1.65倍风险(HR=1.65;95%CI=1.04-2.61;P=0.032)。而单核苷酸多态性rs1885068不同基因型与大动脉粥样硬化性卒中和脑出血的长期预后无相关性。结论单核苷酸多态性rs1885068与腔隙性脑梗死的长期预后相关,是其预后的强预测因子。
Objective To investigate the relationship between different genotypes of SNP rs1885068 and long-term prognosis of different stroke subtypes. Methods A prospective cohort study design was used. After about 4.5 years of follow-up of patients with different subtypes of stroke, the recurrent and all-cause deaths of patients with stroke were recorded. The correlation between different genotypes of SNP rs1885068 and long-term prognosis of stroke patients was analyzed. Polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to detect the genotype of SNP rs1885068 in stroke patients. Results The follow-up of patients with different subtypes of stroke revealed a significant association of SNP rs1885068 with long-term prognosis in patients with lacunar infarcts (log-rank P = 0.034). Cox proportional hazard model adjusted for age, gender, hypertension, diabetes mellitus, smoking history, and history of alcohol consumption showed a single SNP rs1885068 T allele increased 1.65-fold risk of recurrent stroke and all-cause mortality (HR 1.65 ; 95% CI = 1.04-2.61; P = 0.032). The single nucleotide polymorphism rs1885068 different genotypes with atherosclerotic stroke and cerebral hemorrhage no long-term prognosis. Conclusion Single nucleotide polymorphism rs1885068 is associated with long-term prognosis of lacunar infarcts and is a strong predictor of prognosis.