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目的 观察肾综合征出血热 (HFRS)灭活疫苗在黑线姬鼠型为主的混合型疫区使用的安全性、血清学及流行病学效果。方法 1994年 7月至 2 0 0 0年 7月在HFRS高发区 浙江省建德市采用HFRS (Ⅰ型 )灭活疫苗免疫接种 ,逐年测定抗体和观察发病情况。结果 疫苗基础免疫后抗体阳转率为 5 0 % ,1年后抗体阳转率和平均滴度均明显下降 ;5年后未能检出中和抗体 ,荧光抗体阳性率为 10 %。免疫后 7年内未发现病例 ,与对照组比较 ,保护率为 82 49%。结论 HFRS (Ⅰ型 )灭活疫苗具有良好的免疫效果和现场流行病学保护作用。
Objective To observe the safety, serological and epidemiological effects of HFRS inactivated vaccine on mixed-type epidemic area of Apodemus agrarius. Methods From July 1994 to July 2000, HFRS (type Ⅰ) inactivated vaccine was used in Jiande City, a high incidence area of HFRS in China. The antibody and observed incidence were measured yearly. Results The positive rate of antibody positive immunization after vaccination was 50%. The antibody positive rate and the average titer decreased after one year. The neutralizing antibody was not detected after 5 years. The positive rate of fluorescent antibody was 10%. No cases were found within 7 years after immunization, compared with the control group, the protection rate was 82.49%. Conclusion HFRS (type I) inactivated vaccine has good immunogenicity and field epidemiological protection.