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肝细胞癌(HCC)是世界范围内发病率非常高的恶性肿瘤之一。HBV和HCV感染是肝细胞癌发生的主要致病因素。乙型肝炎病毒x蛋白(hepatitis B virus x protein,HBx)是HBV基因组x区编码的一种多功能蛋白,在肝细胞癌发生中起重要作用。HBV抗原表达可引起氧化应激(oxidative stress,OS)致DNA损伤(DNA damage)。研究发现DNA损伤反应的异常是肿瘤发生早期的重要机制。本文重点就HBx对DNA损伤反应的影响及这一影响作用与肝细胞癌发生关系的研究进展做一综述。
Hepatocellular carcinoma (HCC) is one of the most malignant tumors in the world. HBV and HCV infection are the major causative agents of HCC. Hepatitis B virus x protein (HBx) is a multifunctional protein encoded by the x genome of HBV genome, which plays an important role in the development of hepatocellular carcinoma. HBV antigen expression can cause DNA damage caused by oxidative stress (OS). The study found that abnormal DNA damage response is an important mechanism of early tumorigenesis. This article focuses on the impact of HBx on DNA damage response and the impact of this effect on the development of hepatocellular carcinoma are reviewed.