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目的:观察陆军某部官兵幽门螺杆菌(HP)感染情况及根除HP感染对肠易激综合征(IBS)患病情况的影响。方法:随机抽取陆军某部男性官兵1438例,采用13C尿素呼气试验(13C-UBT)检测HP感染情况,参考IBS罗马Ⅲ诊断标准制定IBS问卷调查官兵IBS患病情况。以自愿接受根除HP治疗的IBS官兵60例为观察组,给予四联方案根除治疗;同时选择生活及训练相仿的HP感染官兵60例为对照组,未进行药物治疗。治疗结束4周后复查13C尿素呼气试验,3个月后分别对观察组及对照组进行第2次IBS问卷调查,分析根除HP对IBS患病情况的影响。结果:本组陆军某部官兵HP感染率45.9%,HP感染官兵IBS患病率28.0%,显著高于无HP感染者的23.3%(P<0.05)。观察组根除HP感染后,重度IBS比例非常显著低于根除前,轻度IBS比例非常显著高于根除前(P<0.01);对照组2次IBS评分轻度、中度及重度构成比差异不显著(P>0.05)。结论:HP感染官兵IBS患病率显著增高,根除HP可减轻重度IBS患者的症状。
OBJECTIVE: To observe the influence of Helicobacter pylori (HP) infection and the eradication of HP infection on the prevalence of irritable bowel syndrome (IBS) in the army. Methods: A total of 1438 male officers and men of a certain army were recruited. The 13C urea breath test (13C-UBT) was used to detect the HP infection. The IBS questionnaire was used to determine the prevalence of IBS according to IBS Rome III diagnostic criteria. Sixty cases of IBS officers and soldiers who voluntarily accepted HP eradication were selected as the observation group and were given the quadruple protocol eradication therapy. Meanwhile, 60 HP infection officers and soldiers whose life and training were similar were selected as the control group without medical treatment. Four weeks after the end of treatment, the 13C urea breath test was repeated. After 3 months, the second IBS questionnaire was conducted in the observation group and the control group respectively to analyze the influence of eradicating HP on the prevalence of IBS. Results: The HP infection rate was 45.9%, and the prevalence rate of IBS was 28.0%, which was significantly higher than that of the non-HP infected patients (23.3%, P <0.05). In the observation group, the proportion of severe IBS after eradication of HP infection was significantly lower than that before eradication, and the rate of mild IBS was significantly higher than that before eradication (P <0.01). The difference of mild, moderate and severe constitutional ratio Significant (P> 0.05). Conclusion: The prevalence of IBS in HP infected officers is significantly higher. Eradication of HP can reduce the symptoms of severe IBS patients.